3M-002 (CL-075) is a selective TLR8 agonist that induces activation of NF-κB at 0.4 uM.
3M-002 (CL-075) induces similar cytokine profiles from human PBMC compared with TLR8 agonist ssRNA.
3M-002 (CL-075) effectively stimulates IL-12 production from mDC, but not pDC.
3M-002 (CL-075) induces TNF-α and IL-12 at 0.1 uM from monocytes and monocyte-derived DC (Mo-DC).
Physicochemical Properties
M.Wt
243.33
Formula
C13H13N3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-propylthiazolo[4,5-c]quinolin-4-amine
References
1. Gorden KB, et al. J Immunol. 2005 Feb 1;174(3):1259-68.
2. Spranger S, et al. J Immunol. 2010 Jul 1;185(1):738-47.
3. Makni-Maalej K, et al. J Leukoc Biol. 2015 Jun;97(6):1081-7.
