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AMG650

Chemical Structure : AMG650

CAS No.: 2410796-79-9

AMG650 (Sovilnesib, AMG 650)

Catalog No.: PC-72904Not For Human Use, Lab Use Only.

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A for treatment of advanced solid tumors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A for treatment of advanced solid tumors.
KIF18A is a mitotic kinesin motor protein that regulates chromosome positioning during cell division and is overexpressed in a subset of human cancers.

Physicochemical Properties

M.Wt 564.653
Formula C26H34F2N6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

References

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