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AZ-3451

Chemical Structure : AZ-3451

CAS No.: 2100284-59-9

AZ-3451 (AZ 3451;AZ3451)

Catalog No.: PC-60321Not For Human Use, Lab Use Only.

AZ-3451 (AZ 3451, AZ3451) is a potent, and selective PAR2 antagonist with Kd of 13.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ-3451 (AZ 3451, AZ3451) is a potent, and selective PAR2 antagonist with Kd of 13.5 nM; shows excellent selectivity over PAR1 and PAR4 (>50 uM).

Physicochemical Properties

M.Wt 571.475
Formula C30H27BrN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide

References

1. Cheng RKY, et al. Nature. 2017 May 4;545(7652):112-115.

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