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BHV-8000

Chemical Structure : BHV-8000

CAS No.: 2222137-86-0

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BHV-8000 (TLL-041)

Catalog No.: PC-24435Not For Human Use, Lab Use Only.

BHV-8000 (TLL-041) is a potent, highly selective, oral, brain-penetrant dual TYK2/JAK1 inhibitor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BHV-8000 (TLL-041) is a potent, highly selective, oral, brain-penetrant dual TYK2/JAK1 inhibitor.
BHV-8000 effectively blocks Th17 cell generation, Type I IFN signaling, and inflammation.

Physicochemical Properties

M.Wt 296.33
Formula C16H16N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,5S)-Tetrahydro-5-(2-methyl-1H-furo[3,2-b]imidazo[4,5-d]pyridin-1-yl)-2H-pyran-2-acetonitrile

References

1. Patent WO2018067422 A1.

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