BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
BI 1467335 (PXS-4728A) displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases.
BI 1467335 (PXS-4728A) diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.
