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BMS-204493

Chemical Structure : BMS-204493

CAS No.: 215030-90-3

BMS-204493 (BMS 493;BMS204493)

Catalog No.: PC-70293Not For Human Use, Lab Use Only.

BMS-204493 (BMS493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-204493 (BMS493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM.
BMS-204493 (BMS493) prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.
BMS-204493 (BMS493) blocks the ATRA-induced vasorelaxation.

Physicochemical Properties

M.Wt 404.5
Formula C29H24O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]benzoic acid

References

1. García-Rodríguez J, et al. Bioorg Med Chem. 2014 Feb 15;22(4):1285-302.

2. Das BC, et al. Tetrahedron Lett. 2012 Mar 14;53(11):1316-1318.

3. Wang Y, et al. Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H51-7.

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