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Chemical Structure : BMS-204493
CAS No.: 215030-90-3
Catalog No.: PC-70293Not For Human Use, Lab Use Only.
BMS-204493 (BMS493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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BMS-204493 (BMS493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM.
BMS-204493 (BMS493) prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.
BMS-204493 (BMS493) blocks the ATRA-induced vasorelaxation.
| M.Wt | 404.5 | |
| Formula | C29H24O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]benzoic acid |
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1. García-Rodríguez J, et al. Bioorg Med Chem. 2014 Feb 15;22(4):1285-302.
2. Das BC, et al. Tetrahedron Lett. 2012 Mar 14;53(11):1316-1318.
3. Wang Y, et al. Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H51-7.
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