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Chemical Structure : BP-897
Catalog No.: PC-61736Not For Human Use, Lab Use Only.
BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.
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BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM; displays 70 times lower affinity for D2 (Ki=61 nM), low affinities for D1 and D4 (Ki= 3 and 0.3 uM) and α1 and α2 adrenergic receptor (Ki=60 and 83 nM), negligible affinities (Ki>1 uM) for muscarinic, histamine and opiate receptors; inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects.
Parkinson Disease
Phase 2 Discontinued
| M.Wt | 417.553 | |
| Formula | C26H31N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pilla M, et al. Nature. 1999 Jul 22;400(6742):371-5.
2. Wood MD, et al. Eur J Pharmacol. 2000 Oct 27;407(1-2):47-51.
3. Wicke K, et al. Eur J Pharmacol. 2001 Jul 20;424(2):85-90.
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