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Chemical Structure : BRD-4770
CAS No.: 1374601-40-7
Catalog No.: PC-45050Not For Human Use, Lab Use Only.
A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $348 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BRD-4770 is a SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells.
BRD-4770 decreases H3K9 trimethylation level in PANC-1 cells with EC50 of 5 uM.
BRD-4770 induces senescence, and inhibits both anchorage-dependent and -independent proliferation in PANC-1 cells.
BRD-4770 also increases LC3-II levels and the autophagosome number in PANC-1 cells combined with Gossypol.
| M.Wt | 413.4684 | |
| Formula | C25H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester |
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1. Yuan Y, et al. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
2. Yuan Y, et al. Cell Death Dis. 2013 Jun 27;4:e690.
3. Zhang X, et al. Toxicol Appl Pharmacol. 2016 Aug 1;304:42-7.
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