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Bisperoxovanadium

Chemical Structure : Bisperoxovanadium

CAS No.:

Bisperoxovanadium (Bisperoxovanadium(phen);bpV(phen) potassium hydrate)

Catalog No.: PC-62443Not For Human Use, Lab Use Only.

Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM).
    Bisperoxovanadium activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.

    Physicochemical Properties

    M.Wt 404.3
    Formula C12H8N2O5V • K+(H2O)3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    References

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