CASK inhibitor 18

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Chemical Structure : CASK inhibitor 18

Catalog No.: PC-72703Not For Human Use, Lab Use Only.

CASK chemical probe 18 is a highly potent and selective CASK inhibitor with IC50 of 22 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CASK chemical probe 18 is a highly potent and selective CASK inhibitor with IC50 of 22 nM.
CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) is a member of the MAGUK (membrane-associated guanylate kinase) family that functions as neurexin kinases with roles implicated in neuronal synapses and trafficking.
CASK chemical probe 18 is a first chemical probe for studying the biological roles of CASK.

Physicochemical Properties

M.Wt	610.351
Formula	C24H30Br2N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide

References

1. Nadine Russ, et al. J Med Chem. 2021 Oct 14;64(19):14358-14376.

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