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Chemical Structure : CCT-018159
Catalog No.: PC-61633Not For Human Use, Lab Use Only.
CCT-01815 is a novel potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM.
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CCT-01815 is a novel potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM; shows a mean cellular GI50 of 5.3 uM across a panel of human cancer cell lines; causes cell cytostasis associated with a G(1) arrest and induces apoptosis, also inhibites key endothelial and tumor cell functions implicated in invasion and angiogenesis; significantly reduces transcription factor HNF4A protein levels in iPSC-derived hepatic progenitor cells.
| M.Wt | 352.39 | |
| Formula | C20H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jing R, et al. Development. 2017 May 15;144(10):1764-1774.
2. Sharp SY, et al. Cancer Res. 2007 Mar 1;67(5):2206-16.
3. Cheung KM, et al. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43.
4. Beloueche-Babari M, et al. Oncotarget. 2010 Jul;1(3):185-97.
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