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Chemical Structure : CCT-244747
CAS No.: 1404095-34-6
Catalog No.: PC-45429Not For Human Use, Lab Use Only.
CCT-244747 (CCT244747) is a potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $120 | In stock | |
| 10 mg | $192 | In stock | |
| 25 mg | $360 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CCT-244747 (CCT244747) is a potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM.
CCT-244747 displays 75-fold selectivity against FLT3 and >1,000-fold selectivity against CHK2 and CDK1.
CCT-244747 inhibits cellular CHK1 activity (IC50=29-170nM), significantly enhances the cytotoxicity of several anticancer drugs and abrogates drug-induced S and G2 arrest in multiple tumor cell lines.
CCT-244747 enhances antitumor activity of gemcitabine and irinotecan in vivo.
| M.Wt | 408.457 | |
| Formula | C20H24N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]- |
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1. Walton MI, et al. Clin Cancer Res. 2012 Oct 15;18(20):5650-61.
2. Lainchbury M, et al. J Med Chem. 2012 Nov 26;55(22):10229-40.
3. Barker HE, et al. Mol Cancer Ther. 2016 Sep;15(9):2042-54.
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