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CCT-245737

Chemical Structure : CCT-245737

CAS No.: 1489389-18-5

CCT-245737 (SRA-737;SRA737;SRA 737;CCT245737;CCT 245737)

Catalog No.: PC-45574Not For Human Use, Lab Use Only.

CCT-245737 (SRA-737) is a highly potent, selective, ATP-competitive inhibitor of Chk1 with IC50 of 1.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CCT-245737 (SRA-737) is a highly potent, selective, ATP-competitive inhibitor of Chk1 with IC50 of 1.3 nM.
CCT-245737 displays weak inhibition on Chk2 (IC50=2440 nM).
CCT-245737 inhibits genotoxic-induced CHK1 activity (pS296 CHK1) and cell cycle arrest (pY15 CDK1) both in vitro and in human tumor xenografts.
CCT-245737 showes significant single-agent activity against a MYC-driven mouse model of B-cell lymphoma.
CCT-245737 is orally active.

Physicochemical Properties

M.Wt 379.3398
Formula C16H16F3N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

2-Pyrazinecarbonitrile, 5-[[4-[[(2R)-2-morpholinylmethyl]amino]-5-(trifluoromethyl)-2-pyridinyl]amino]-

References

1. Osborne JD, et al. J Med Chem. 2016 Jun 9;59(11):5221-37.

2. Walton MI, et al. Oncotarget. 2016 Jan 19;7(3):2329-42.

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