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Chemical Structure : CPI 0610
CAS No.: 1845726-14-8
Catalog No.: PC-62282Not For Human Use, Lab Use Only.
Pelabresib (CPI 0610) is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote |
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Pelabresib (CPI 0610) is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
Pelabresib (CPI 0610) is a shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8.
Pelabresib (CPI 0610) is a has an IC50 of 0.18 uM in MYC RNA expression assay.
Pelabresib (CPI 0610) is a demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model.
| M.Wt | 365.817 | |
| Formula | C20H16ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[e]isoxazolo[5,4-c]azepin-4-yl)acetamide |
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1. Albrecht BK, et al. J Med Chem. 2016 Feb 25;59(4):1330-9.
2. Siu KT, et al. Leukemia. 2017 Jan 3. doi: 10.1038/leu.2016.355.
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