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Chemical Structure : CYT387 sulfate salt
CAS No.: 1056636-06-6
Catalog No.: PC-42752Not For Human Use, Lab Use Only.
A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $84 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock |
Bulk size, bulk discount!
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A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM; shows significantly less activity against other kinases, including JAK3 (IC50=155 nM); inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM; inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).
Bone Cancer
Phase 3 Clinical
| M.Wt | 610.6168 | |
| Formula | C23H26N6O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 6.1 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, sulfate (1:2) |
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1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.
2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.
3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.
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