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Chemical Structure : Compound L
Catalog No.: PC-60419Not For Human Use, Lab Use Only.
Compound L (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.
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Compound L (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay; impairs DNA-PKCS autophospho-rylation at the Ser2056 residue, inhibits the Ku-dependent activation of the DNA-PKCS kinase in human cells; synergistically sensitizes human cell lines to radiation treatment, indicating a clear potential to diminish DSB repair.
| M.Wt | 437.431 | |
| Formula | C22H20FN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Weterings E, et al. DNA Repair (Amst). 2016 Jul;43:98-106.
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