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EB-3D

Chemical Structure : EB-3D

CAS No.: 1839150-63-8

EB-3D (ChoKα inhibitor EB-3D)

Catalog No.: PC-35395Not For Human Use, Lab Use Only.

EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

EB-3D is a potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines.
EB-3D demonstrates in vitro antiproliferative effects against HeLa (IC50=79 nM), RS4,11 (IC50=45 nM), A549 (IC50=27 nM) and MDA-MB-231 (IC50=100 nM).
EB-3D displays excellent antiproliferative activity against a wide cohort of T-leukemic cell lines with GI50 of 0.9 nM (MOLT-16 cell)-479 nM (CCRF-CEM), reduces the intracellular pool of PCho, but also inhibits the synthesis of choline-containing lipids.
 induces G0/G1 arrest that lead to apoptosis in leukemia cell lines; affects AMPK-mTOR signaling pathway, synergizes with both dexamethasone and L-asparaginase.

Physicochemical Properties

M.Wt 644.452
Formula C30H36Br2N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridinium) bromide

References

1. Schiaffino-Ortega S, et al. Sci Rep. 2016 Mar 31;6:23793.

2. Mariotto E, et al. Biochem Pharmacol. 2018 Jul 10. pii: S0006-2952(18)30272-7.

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