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ENPP1 inhibitor 32

Chemical Structure : ENPP1 inhibitor 32

CAS No.: 2298391-60-1

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ENPP1 inhibitor 32

Catalog No.: PC-38280Not For Human Use, Lab Use Only.

ENPP1 inhibitor 32 is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ENPP1 inhibitor 32 is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM,
ENPP1 inhibitor 32 prevents cGAMP degradation in mouse and human plasma at nanomolar concentrations (IC95=40 nM).
ENPP1 inhibitor 32 exhibits excellent physicochemical and pharmacokinetic properties, and delays tumor growth in a breast cancer mouse model.

Physicochemical Properties

M.Wt 351.343
Formula C16H22N3O4P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (3.5 mg/mL)
Chemical Name/SMILES

P-[2-[1-(8-Methoxy-4-quinazolinyl)-4-piperidinyl]ethyl]phosphonic acid

References

1. Jacqueline A Carozza, et al. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5.

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