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Chemical Structure : EPZ-015866
CAS No.: 1616391-87-7
Catalog No.: PC-42097Not For Human Use, Lab Use Only.
EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
EPZ-015866 (GSK-591, GSK-3203591) shows excellent selectivity against other PMT enzymes observed with EPZ015666.
EPZ-015866 (GSK-591, GSK-3203591) inhibits the proliferation of Z-138 cells with IC50 of 62 nM.
| M.Wt | 380.4833 | |
| Formula | C22H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Pyridinecarboxamide, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]- |
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1. Duncan KW, et al. ACS Med Chem Lett. 2015 Dec 2;7(2):162-6.
2. Gerhart SV, et al. Sci Rep. 2018 Jun 26;8(1):9711.
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