Chemical Structure : EYU688 (NITD-688)
CAS No.:
2407227-31-8
EYU688 (NITD-688)
(NITD688)
Catalog No.: PC-23167Not For Human Use, Lab Use Only.
EYU688 (NITD-688) is a potent, specific pan-serotype inhibitor of dengue virus (DENV) NS4B protein, shows EC50 of 8-38 nM against all four DENV serotypes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EYU688 (NITD-688) is a potent, specific pan-serotype inhibitor of dengue virus (DENV) NS4B protein, shows EC50 of 8-38 nM against all four DENV serotypes.
EYU688 (NITD-688) displays an EC50 value of 0.94 nM in PBMCs were infected with DENV-2.
EYU688 (NITD-688) shows potent activity against DENV (EC50 = 0.023 μM) in CPE assay, but not other flaviviruses or CHIKV.
EYU688 (NITD-688) directly binds to wild-type but not mutant NS4B with mutations T215A and A222V.
EYU688 (NITD-688) at 10, 30, or 100 mg/kg twice daily (BID) for 3 days or 30 mg/kg once daily (QD) for 3 days (oral gavage once daily (QD) or twice daily (BID) and was formulated in 0.5% methyl cellulose and 0.5% Tween 80 in water) reduces DENV-2 viremia during acute or delayed treatment of infected AG129 mice.
Physicochemical Properties
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M.Wt
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500.68
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Formula
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C25H32N4O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-cyano-5-(cyclohexylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide
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References
1. Moquin SA, et al. Sci Transl Med. 2021 Feb 3;13(579):eabb2181.
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