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Chemical Structure : EYU688 (NITD-688)
Catalog No.: PC-23167Not For Human Use, Lab Use Only.
EYU688 (NITD-688) is a potent, specific pan-serotype inhibitor of dengue virus (DENV) NS4B protein, shows EC50 of 8-38 nM against all four DENV serotypes.
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EYU688 (NITD-688) is a potent, specific pan-serotype inhibitor of dengue virus (DENV) NS4B protein, shows EC50 of 8-38 nM against all four DENV serotypes.
EYU688 (NITD-688) displays an EC50 value of 0.94 nM in PBMCs were infected with DENV-2.
EYU688 (NITD-688) shows potent activity against DENV (EC50 = 0.023 μM) in CPE assay, but not other flaviviruses or CHIKV.
EYU688 (NITD-688) directly binds to wild-type but not mutant NS4B with mutations T215A and A222V.
EYU688 (NITD-688) at 10, 30, or 100 mg/kg twice daily (BID) for 3 days or 30 mg/kg once daily (QD) for 3 days (oral gavage once daily (QD) or twice daily (BID) and was formulated in 0.5% methyl cellulose and 0.5% Tween 80 in water) reduces DENV-2 viremia during acute or delayed treatment of infected AG129 mice.
| M.Wt | 500.68 | |
| Formula | C25H32N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moquin SA, et al. Sci Transl Med. 2021 Feb 3;13(579):eabb2181.
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