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FLX-475

Chemical Structure : FLX-475

CAS No.: 2174938-78-2

FLX-475 (Tivumecirnon, FLX 475, FLX475)

Catalog No.: PC-61981Not For Human Use, Lab Use Only.

FLX-475 (Tivumecirnon) is a novel potent, selective CCR4 antagonist, blocks the migration of regulatory T cells (Treg) specifically into tumors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FLX-475 (Tivumecirnon) is a novel potent, selective CCR4 antagonist, blocks the migration of regulatory T cells (Treg) specifically into tumors.

    Physicochemical Properties

    M.Wt 543.42
    Formula C24H27Cl2F3N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-((R)-3-(1-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)azetidin-3-yl)piperidin-1-yl)ethan-1-ol

    References

    1. Adam Grant, et al. Cancer Res 15 March 2024; 84 (6_Supplement): 2485.

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