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You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Deubiquitinase (DUB)-FT-827
FT-827

Chemical Structure : FT-827

CAS No.: 1959537-86-0

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FT-827 (FT827, FT 827)

Catalog No.: PC-60087Not For Human Use, Lab Use Only.

FT-827 is a novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).

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Purity & Documentation Purity: 99.02% (HPLC) Select Batch:

Biological Activity

FT-827 is a novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
FT-827 modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs)

Physicochemical Properties

M.Wt 548.618
Formula C27H28N6O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide

References

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.

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