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Chemical Structure : FT-827
CAS No.: 1959537-86-0
Catalog No.: PC-60087Not For Human Use, Lab Use Only.
FT-827 is a novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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FT-827 is a novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
FT-827 modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs)
| M.Wt | 548.618 | |
| Formula | C27H28N6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide |
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1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
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