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Chemical Structure : GB-83
Catalog No.: PC-61618Not For Human Use, Lab Use Only.
GB-83 is a selective, reversible PAR2 (Protease-activated receptor 2) antagonist with IC50 of 2 uM.
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GB-83 is a selective, reversible PAR2 (Protease-activated receptor 2) antagonist with IC50 of 2 uM.
GB-83 prevents upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases in human atrial tissue.
GB-83 reverses neutrophil elastase-induced synovitis and pain in mice.
| M.Wt | 548.72 | |
| Formula | C32H44N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barry GD, et al. J Med Chem. 2010 Oct 28;53(20):7428-40.
2. Bukowska A, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):114-23.
3. Muley MM, et al. Br J Pharmacol. 2016 Feb;173(4):766-77.
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