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Chemical Structure : GDC-9545
CAS No.: 1953133-47-5
Catalog No.: PC-72786Not For Human Use, Lab Use Only.
GDC-9545 (Giredestrant) is an efficient and potent selective estrogen receptor degrader (SERD) and a full antagonist.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $548 | In stock | |
| 50 mg | $858 | In stock | |
| 100 mg | Get quote |
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GDC-9545 (Giredestrant) is an efficient and potent selective estrogen receptor degrader (SERD) and a full antagonist.
GDC-9545 exhibited better antiproliferation activity than known SERDs across multiple cell lines.
GDC-9545 exhibits low drug-drug interaction liability and demonstrates excellent in vitro and in vivo safety profiles.
GDC-9545 induced tumor regressions either as a single agent or in combination with a CDK4/6 inhibitor in an ESR1Y537S mutant PDX or a wild-type ERα tumor model.
| M.Wt | 522.564 | |
| Formula | C27H31F5N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (5.2 mg/mL) |
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| Chemical Name/SMILES |
3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol |
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1. Liang J, et al. J Med Chem. 2021 Aug 26;64(16):11841-11856.
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