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GSK-2879552

Chemical Structure : GSK-2879552

CAS No.: 1401966-69-5

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GSK-2879552 (GSK2879552)

Catalog No.: PC-45495Not For Human Use, Lab Use Only.

GSK-2879552 is a potent, selective irreversible inhibitor of LSD1 with Ki app of 1.7 uM.

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10 mg $128 In stock
25 mg $198 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK-2879552 is a potent, selective irreversible inhibitor of LSD1 with Ki app of 1.7 uM.
GSK-2879552 shows good selectivity against LSD2, MAO-A, MAO-B, D-amino acid oxidase and LoxL2.
GSK-2879552 exhibits growth inhibition (EC50=2-240 nM) in sensitive cell lines.
GSK-2879552 is orally bioavailable.

Physicochemical Properties

M.Wt 364.4806
Formula C23H28N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzoic acid, 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-

References

1. Mohammad HP, et al. Cancer Cell. 2015 Jul 13;28(1):57-69.

2. Huang M, et al. Cancer Lett. 2017 Jul 10;398:12-21.

3. Maes T, et al. Epigenomics. 2015;7(4):609-26.

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