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Chemical Structure : GSK-6853
CAS No.: 1910124-24-1
Catalog No.: PC-42090Not For Human Use, Lab Use Only.
GSK-6853 (GSK6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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GSK-6853 (GSK6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.
GSK-6853 displays>1600-fold selectivity over others bromodomains (BRPF2/3, BRD4 BD1/BD2).
GSK-6853 displaces NanoLuc-tagged BRPF1 bromodomain from Halo-tagged histone H3.3 (IC50=20 nM) and disrupts chromatin binding in cell assays.
GSK-6853 demonstrates properties suitable for cellular and in vivo studies.
| M.Wt | 409.4815 | |
| Formula | C22H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy- |
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1. Bamborough P, et al. ACS Med Chem Lett. 2016 May 9;7(6):552-7.
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