Chemical Structure : GW406108X
Catalog No.: PC-35945Not For Human Use, Lab Use Only.
GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays.
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GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays; GW108X displays a preference for Kif15 over the other mitotic motors, with 30 µM of GW108X inhibiting Kif15 MT gliding by 98.9% ± 0.2% while only inhibiting Eg5 by 19.8% ± 4.3%, HSET by 5.3% ± 2.9% and Kif18A by 4.9%; inhibits the MT-stimulated ATPase and MT gliding activity of Kif15 either by inhibiting ATP binding or by inhibiting MT binding by the motorl; shows a distinct mechanism of action compared with the Kif15 inhibitor, Kif15-IN-1.
M.Wt | 400.211 | |
Formula | C20H11Cl2NO4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Dumas ME, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):148-154.
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