Chemical Structure : HOSU-53 sodium
CAS No.:
2659233-17-5
HOSU-53 sodium
(HOSU53 sodium)
Catalog No.: PC-22221Not For Human Use, Lab Use Only.
HOSU-53 sodium is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HOSU-53 sodium is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.
HOSU-53 shows relatively similar inhibitory potency across mouse, rat, and dog DHODH enzyme.
HOSU-53 displays little to no activity against a panel of approximately 450 human kinases at 10 μM.
HOSU-53 exhibits potent in vitro antileukemic activity with median IC50 of 120.5 nM, promotes in vitro innate phagocytic function.
HOSU-53 (30 mg/kg) demonstrates in vivo single-agent antileukemic activity, results in superior in vivo outcome using AML disseminated xenograft model.
HOSU-53 demonstrates in vivo synergy with approved targeted AML therapies.
Physicochemical Properties
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M.Wt
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437.45
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Formula
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C26H21FNNaO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-Quinolinecarboxylic acid, 2-(3′-butoxy[1,1′-biphenyl]-4-yl)-6-fluoro-, sodium salt (1:1)
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References
1. Ola A Elgamal, et al. JCI Insight. 2024 Apr 22;9(8):e173646.
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