Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JNJ-A07
CAS No.: 2135640-93-4
Catalog No.: PC-72500Not For Human Use, Lab Use Only.
JNJ-A07 is a highly potent, highly specific dengue virus (DENV) inhibitor targeting the NS3-NS4B interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JNJ-A07 is a highly potent, highly specific dengue virus (DENV) inhibitor targeting the NS3-NS4B interaction.
JNJ-A07 displays high potency with nanomolar to picomolar activity against a panel of 21 clinical isolates that represent the natural genetic diversity of known genotypes and serotypes.
JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between viral proteins NS3 and NS4B.
JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.
| M.Wt | 578.969 | |
| Formula | C28H26ClF3N2O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
100 mM in DMSO (579 mg/mL) |
|
| Chemical Name/SMILES |
(+)-4-[3-[[1-(4-Chlorophenyl)-2-[2,3-dihydro-6-(trifluoromethoxy)-1H-indol-1-yl]-2-oxoethyl]amino]-5-methoxyphenoxy]butanoic acid |
|
1. Suzanne J F Kaptein, et al. Nature. 2021 Oct;598(7881):504-509.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
