K-777 |CAS:749860-43-3 Probechem Biochemicals

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Chemical Structure : K-777

K-777 (K 777;K777)

Catalog No.: PC-61984Not For Human Use, Lab Use Only.

K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
K-777 induces CCR4 internalization, reduces cell surface CCR4.

Physicochemical Properties

M.Wt	641.5
Formula	C28H32F4IN5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-(4-((2,4-difluorobenzyl)amino)-5-(2,4-difluorophenyl)pyrimidin-2-yl)piperidin-4-yl)-1-methylpiperidin-1-ium

References

1. Sato T, et al. Pharmacology. 2013;91(5-6):305-13.

2. Solari R, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt B):169-77.

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K-777 (K 777;K777)

Biological Activity

Physicochemical Properties

References

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