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Chemical Structure : KSL 128114
Catalog No.: PC-49327Not For Human Use, Lab Use Only.
KSL-128114 (KLS 128114) is a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin (KD=0.3 uM), inhibits SARS-CoV-2 infection by blocking the endosomal entry of the virus.
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| 1 g | Get quote |
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KSL-128114 (KLS 128114) is a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin (KD=0.3 uM), inhibits SARS-CoV-2 infection by blocking the endosomal entry of the virus.
KSL-128114 efficiently inhibited SARS-CoV-2 viral infection in in VeroE6 cells (EC50=20 uM) with no or minor effects on cell viability.
KSL-128114 does not bind to ACE2 in our FP-based affinity measurement, and shows 15-fold lower affinity to SNX27 (KD=5 uM).
KSL-128114 is a novel pan-viral entry inhibitor that acts by blocking the endosomal entry pathway, also inhibits a panel of flaviviruses (dengue virus (DENV), West Nile virus 283 (WNV) and tick-born encephalitis virus (TBEV)) and an alphavirus (chikungunya virus (CHIKV)). KSL-128114 shows an inhibitory effect on primary GBM cell viability and significantly extends survival time in a patient-derived xenograft mouse model.
| M.Wt | 2201.628 | |
| Formula | C96H165N39O21 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Linda M Haugaard-Kedström, et al. J Med Chem. 2021 Feb 11;64(3):1423-1434.
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