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LMI-070

Chemical Structure : LMI-070

CAS No.: 1562338-42-4

LMI-070 (NVS-SM1;Branaplam )

Catalog No.: PC-45659Not For Human Use, Lab Use Only.

LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM) that potential treatment of spinal muscular atrophy (SMA).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM) that potential treatment of spinal muscular atrophy (SMA).

Physicochemical Properties

M.Wt 393.4821
Formula C22H27N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.12 mg/mL

Chemical Name/SMILES

Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-

References

1. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.

2. Palacino J, et al. Nat Chem Biol. 2015 Jul;11(7):511-7.

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