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Chemical Structure : LOC-14
CAS No.: 877963-94-5
Catalog No.: PC-70321Not For Human Use, Lab Use Only.
LOC-14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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LOC-14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM.
LOC14-induced oxidation of PDI has a neuroprotective effect not only in cell culture, but also in corticostriatal brain slice cultures.
LOC-14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.
| M.Wt | 317.41 | |
| Formula | C16H19N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
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1. Kaplan A, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52.
2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50.
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