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ML-241 hydrochloride

Chemical Structure : ML-241 hydrochloride

CAS No.:

ML-241 hydrochloride (ML241 hydrochloride;ML 241 hydrochloride)

Catalog No.: PC-45719Not For Human Use, Lab Use Only.

ML241 Hcl is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML241 Hcl is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM); blocks degradation of p97-dependent proteasome substrate with an IC50 of 3.5 uM; induces caspases 3 and 7 and potently blocks proliferation in HCT15 and SW403 cells.

Physicochemical Properties

M.Wt 408.9238
Formula C23H25ClN4O
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 34 mg/mL

Chemical Name

4-Quinazolinamine, 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-,hydrochloride

References

1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.

3. Fang CJ, et al. ChemMedChem. 2015 Jan;10(1):52-6.

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