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Chemical Structure : Mithramycin A
CAS No.: 18378-89-7
Catalog No.: PC-61350Not For Human Use, Lab Use Only.
Mithramycin A (Plicamycin, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $258 | In stock | |
| 5 mg | $458 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Mithramycin A (Plicamycin, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA.
Mithramycin A binds to the minor groove of DNA at GC-rich sites, induces cancer cell apoptosis and metastasis.
| M.Wt | 1085 | |
| Formula | C52H76O24 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,3S)-3-((1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl)-2-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran- |
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1. Boro A, et al. Int J Cancer. 2012 Nov 1;131(9):2153-64.
2. Lee TJ, et al. Mol Cancer Ther. 2006 Nov;5(11):2737-46.
3. Majee S, et al. Biochem Pharmacol. 1999 May 1;57(9):981-7.
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