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Chemical Structure : NCT-505 free base
CAS No.: 2231079-74-4
Catalog No.: PC-35950Not For Human Use, Lab Use Only.
NCT-505 free base (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NCT-505 free base (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
NCT-505 also exhibits IC50 of 30 nM in MIA PaCa-2 Aldefluor cell-based assays.
NCT-505 demonstrates target engagement in CETSA asssay (EC50=3.4 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.
| M.Wt | 521.611 | |
| Formula | C27H28FN5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)-4-phenylpiperidine-4-carbonitrile |
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1. Yang SM, et al. J Med Chem. 2018 Jun 14;61(11):4883-4903.
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