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Chemical Structure : NSC 177223
CAS No.: 36707-00-3
Catalog No.: PC-38489Not For Human Use, Lab Use Only.
NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $188 | In stock | |
| 5 mg | $388 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation.
NSC 177227 (API-1) does not interfere with PI3K, PDK1, and mTORC1/2 complexes.
NSC 177227 (API-1) is selective for Akt over the AGC kinase members PKA, PKC, and SGK and other signaling molecules ERK, JNK, p38, and STAT3.
NSC 177227 (API-1) inhibits constitutively active Akt and its downstream targets, inhibits cell growth and induces apoptosis in the cells with hyperactivated Akt.
NSC 177227 (API-1) exhibits anti-tumor activity in cancer cell lines with hyperactivated Akt in mouse xenografts.
| M.Wt | 337.3 | |
| Formula | C13H15N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-amino-8-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide |
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1. Donghwa Kim, et al. J Biol Chem. 2010 Mar 12;285(11):8383-94.
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