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Chemical Structure : PBF509
CAS No.: 1337962-47-6
Catalog No.: PC-35779Not For Human Use, Lab Use Only.
PBF509 (Taminadenant, PBF-509, NIR 178) is a novel selective and potent Adenosine A2A Receptor (A2AR) antagonist, antagonizes A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 and 8.2 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $318 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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PBF509 (Taminadenant, PBF-509, NIR 178) is a novel selective and potent Adenosine A2A Receptor (A2AR) antagonist, antagonizes A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 and 8.2 nM, respectively.
PBF509 (orally) antagonized haloperidol-mediated catalepsy, reduced pilocarpine-induced tremulous jaw movements and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine (L-DOPA) in unilaterally 6-OHDA-lesioned rats.
PBF509 (3 mg/kg) inhibited L-DOPA-induced dyskinesia (LID), showing not only its efficacy on reversing parkinsonian motor impairments but also acting as antidyskinetic agent; increased responsiveness of human tumor-infiltrating lymphocytes when combined with anti-PD-1 or anti-PD-L1.
| M.Wt | 306.127 | |
| Formula | C10H8BrN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine |
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1. Núñez F, et al. Front Pharmacol. 2018 Oct 19;9:1200.
2. Mediavilla-Varela M, et al. Neoplasia. 2017 Jul;19(7):530-536.
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