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Chemical Structure : PDD 00017273
CAS No.: 1945950-21-9
Catalog No.: PC-62412Not For Human Use, Lab Use Only.
PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.
PDD 00017273 inhibits the proliferation of ZR-75-1 cells and MDA-MB-436 with IC50 of 0.2 and 0.8 uM.
PDD 00017273 inhibits DNA repair with differential pharmacology to olaparib; shows no activity against CYP450 isoforms.
PDD 00017273 possesses good aqueous solubility and suitable for in vivo studies.
| M.Wt | 514.619 | |
| Formula | C23H26N6O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide |
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1. James DI, et al. ACS Chem Biol. 2016 Nov 18;11(11):3179-3190.
2. Gravells P, et al. DNA Repair (Amst). 2017 Apr;52:81-91.
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