Atirmociclib (PF-07220060) | CDK4 inhibitor

Chemical Structure : PF-07220060

CAS No.: 2380321-51-5

PF-07220060 (Atirmociclib, PF 07220060)

Catalog No.: PC-49575Not For Human Use, Lab Use Only.

PF-07220060 (Atirmociclib) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3).

Packing	Price	Stock
5 mg	$228	In stock
10 mg	$358	In stock
25 mg	$558	In stock
50 mg	$898	In stock
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Biological Activity

PF-07220060 (Atirmociclib) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3).

Physicochemical Properties

M.Wt	462.95
Formula	C23H28ClFN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4R)-4-((5-chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)amino)tetrahydro-2H-pyran-3-ol

References

1. Patent WO2019207463A1.
2. Lars Anders, et al. Cancer Res (2024) 84 (7_Supplement): ND12.

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PF-07220060 (Atirmociclib, PF 07220060)

Biological Activity

Physicochemical Properties

References

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