Catalog No.: PC-49344Not For Human Use, Lab Use Only.
PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).
PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).
PIKfyve inhibitor 17 displays efficacious inhibition of viral replication in the MHV-nLuc assay with IC50 of 23.5 nM.
PIKfyve inhibitor 17 potently inhibits SARS-CoV-2 replication with IC50 of 19.5 nM in a SARS-CoV-2-nLuc assay in human epithelial A549-ACE2 cells, outperformed remdesivir.
PIKfyve inhibitor 17 reduces uptake of His6-SARS-CoV-2 spike protein by HEK293T-ACE2 cells, inhibits uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein and impacts lysosomal homeostasis.s
