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Chemical Structure : PK-11007
CAS No.: 874146-69-7
Catalog No.: PC-61495Not For Human Use, Lab Use Only.
PK-11007 (PK11007) is a 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells, stabilizes p53 in vitro via selective alkylation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
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| 100 mg | Get quote |
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PK-11007 (PK11007) is a 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells, stabilizes p53 in vitro via selective alkylation.
PK-11007 stabilizes p53 in vitro via selective alkylation of two surface-exposed cysteines without compromising p53 DNA binding activity.
PK-11007 also induces cell death independent of p53, but with highly elevated levels of ROS and induction of ER stress.
| M.Wt | 427.85 | |
| Formula | C15H11ClFN5O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-Chloro-2-((4-fluorobenzyl)sulfonyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide |
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1. Bauer MR, et al. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5271-80.
2. Duffy MJ, et al. Eur J Cancer. 2017 Sep;83:258-265.
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