Catalog No.: PC-62081Not For Human Use, Lab Use Only.
PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria..
PK-7088 (PK7088) is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.
Physicochemical Properties
M.Wt
223.279
Formula
C14H13N3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole
References
1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44.
2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61.
3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.
