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PK-7088

Chemical Structure : PK-7088

CAS No.: 1446352-67-5

PK-7088 (PK7088)

Catalog No.: PC-62081Not For Human Use, Lab Use Only.

PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria..

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Biological Activity

PK-7088 (PK7088) is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.

Physicochemical Properties

M.Wt 223.279
Formula C14H13N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole

References

1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44.

2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61.

3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.

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