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Chemical Structure : PhiKan-083
Catalog No.: PC-70006Not For Human Use, Lab Use Only.
A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM.
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A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM; binds with high affinity to a crevice created by the Y220C mutation in p53 and stabilizes the mutant protein.
| M.Wt | 274.792 | |
| Formula | C16H18N2.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bauer MR, et al. ACS Chem Biol. 2016 Aug 19;11(8):2265-74.
2. Boeckler FM, et al. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.
3. Wiman KG. Oncogene. 2010 Jul 29;29(30):4245-52.
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