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Chemical Structure : Pyr-1
Catalog No.: PC-70099Not For Human Use, Lab Use Only.
Liminib (Pyr-1) is a novel potent, selective, cell permeable and ATP competitive LIMK inhibitor.
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Liminib (Pyr-1) is a novel potent, selective, cell permeable and ATP competitive LIMK inhibitor.
Liminib (Pyr-1) stabilizes microtubules, induces a cell-cycle arrest at the S-G2-M phases, and blocks actin microfilament dynamics through inhibition of cofilin phosphorylation.
Liminib (Pyr-1) blocks the invasion and proliferation of breast cancer cells, including paclitaxel-resistant cells, in vitro and tumor growth and metastasis in vivo in tumor xenograft.
| M.Wt | 382.42 | |
| Formula | C24H18N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Prunier C, et al. Cancer Res. 2016 Jun 15;76(12):3541-52.
2. Prudent R, et al. Cancer Res. 2012 Sep 1;72(17):4429-39.
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