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Pyr-1

Chemical Structure : Pyr-1

CAS No.: 83947-94-8

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Pyr-1 (Liminib;Pyr1)

Catalog No.: PC-70099Not For Human Use, Lab Use Only.

Liminib (Pyr-1) is a novel potent, selective, cell permeable and ATP competitive LIMK inhibitor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Liminib (Pyr-1) is a novel potent, selective, cell permeable and ATP competitive LIMK inhibitor.
Liminib (Pyr-1) stabilizes microtubules, induces a cell-cycle arrest at the S-G2-M phases, and blocks actin microfilament dynamics through inhibition of cofilin phosphorylation.
Liminib (Pyr-1) blocks the invasion and proliferation of breast cancer cells, including paclitaxel-resistant cells, in vitro and tumor growth and metastasis in vivo in tumor xenograft.

Physicochemical Properties

M.Wt 382.42
Formula C24H18N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

5,11-dimethyl-1-oxo-2,6-dihydro-1H-pyrido[4,3-b]carbazol-9-yl benzoate

References

1. Prunier C, et al. Cancer Res. 2016 Jun 15;76(12):3541-52.

2. Prudent R, et al. Cancer Res. 2012 Sep 1;72(17):4429-39.

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