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Chemical Structure : Rpn11 inhibitor 35
CAS No.: 2084868-04-0
Catalog No.: PC-61132Not For Human Use, Lab Use Only.
Rpn11 inhibitor 35 is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $368 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | $1880 | In stock | |
| 250 mg | Get quote |
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Rpn11 inhibitor 35 is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH; inhibits 293T and A549 cells proliferation with IC50 of 2.1 and 3.8 uM, respectively.
| M.Wt | 628.802 | |
| Formula | C30H24N6O2S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
8,8'-disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide) |
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1. Perez C, et al. J Med Chem. 2017 Feb 23;60(4):1343-1361.
2. Li J, et al. Nat Chem Biol. 2017 May;13(5):486-493.
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