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Rpn11 inhibitor 35

Chemical Structure : Rpn11 inhibitor 35

CAS No.: 2084868-04-0

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Rpn11 inhibitor 35

Catalog No.: PC-61132Not For Human Use, Lab Use Only.

Rpn11 inhibitor 35 is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH.

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25 mg $898 In stock
100 mg $1880 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rpn11 inhibitor 35 is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH; inhibits 293T and A549 cells proliferation with IC50 of 2.1 and 3.8 uM, respectively.

Physicochemical Properties

M.Wt 628.802
Formula C30H24N6O2S4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8,8'-disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)

References

1. Perez C, et al. J Med Chem. 2017 Feb 23;60(4):1343-1361.

2. Li J, et al. Nat Chem Biol. 2017 May;13(5):486-493.

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