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SB-218078

Chemical Structure : SB-218078

CAS No.: 135897-06-2

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SB-218078 (SB 218078;SB218078)

Catalog No.: PC-60290Not For Human Use, Lab Use Only.

SB-218078 (SB218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SB-218078 (SB218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
    SB-218078 less potently inhibits Cdc2 and PKC (IC50=250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 uM.
    SB-218078 enhances the cytotoxicity of DNA-damaging agents.

    Physicochemical Properties

    M.Wt 393.4
    Formula C24H15N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5,6,7,8-tetrahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-13,15(14H)-dione

    References

    1. Jackson JR, et al. Cancer Res. 2000 Feb 1;60(3):566-72.

    2. Fishler T, et al. Oncogene. 2010 Jul 15;29(28):4007-17.

    3. Akasaka T, et al. Int J Oncol. 2015 Jan;46(1):63-70.

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