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Chemical Structure : SB-218078
Catalog No.: PC-60290Not For Human Use, Lab Use Only.
SB-218078 (SB218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
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SB-218078 (SB218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
SB-218078 less potently inhibits Cdc2 and PKC (IC50=250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 uM.
SB-218078 enhances the cytotoxicity of DNA-damaging agents.
| M.Wt | 393.4 | |
| Formula | C24H15N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jackson JR, et al. Cancer Res. 2000 Feb 1;60(3):566-72.
2. Fishler T, et al. Oncogene. 2010 Jul 15;29(28):4007-17.
3. Akasaka T, et al. Int J Oncol. 2015 Jan;46(1):63-70.
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