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Chemical Structure : SB 332235
Catalog No.: PC-60622Not For Human Use, Lab Use Only.
SB332235 (SB 332235) is a potent, selective and competitive CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with pKi of 8.92.
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SB332235 (SB 332235) is a potent, selective and competitive CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with pKi of 8.92.
SB332235 inhibits N-Ac-PGP- and CXCL1-induced neutrophil influx and the increased pulmonary tissue MPO levels in micelung tissue homogenates.
SB332235 effectively inhibits smoke-induced inflammatory and mucus hypersecretory changes in rat lung.
SB332235 also attenuates microglial inflammatory reactivity induced by Aβ1-42 intrahippocampal injection in animal model of Alzheimer’s disease.
| M.Wt | 410.66 | |
| Formula | C13H10Cl3N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Braber S, et al. Eur J Pharmacol. 2011 Oct 15;668(3):443-9.
2. Ryu JK, et al. J Neuroinflammation. 2015 Aug 9;12:144.
3. Bizzarri C, et al. Pharmacol Ther. 2006 Oct;112(1):139-49.
4. Stevenson CS, et al. Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22.
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