SCH-527123 |CAS:473727-83-2 Probechem Biochemicals

Chemical Structure : SCH-527123

CAS No.: 473727-83-2

SCH-527123 (SCH527123;Navarixin;SCH 527123;MK-7123)

Catalog No.: PC-42443Not For Human Use, Lab Use Only.

SCH-527123 (Navarixin, MK-7123) is a potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.

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25 mg	$248	In stock
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Biological Activity

SCH-527123 (Navarixin, MK-7123) is a potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
SCH-527123 potently inhibits CXCR2-mediated chemotaxis with IC50 of 3-6 nM.
SCH-527123 inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.

Physicochemical Properties

M.Wt	397.4244
Formula	C21H23N3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-

References

1. Chapman RW, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):486-93.

2. Dwyer MP, et al. J Med Chem. 2006 Dec 28;49(26):7603-6.

3. Gonsiorek W, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):477-85.

4. Singh S, et al. Clin Cancer Res. 2009 Apr 1;15(7):2380-6.

SCH-527123 (SCH527123;Navarixin;SCH 527123;MK-7123)

Biological Activity

Physicochemical Properties

References

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