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Chemical Structure : SHIN2
Catalog No.: PC-38150Not For Human Use, Lab Use Only.
SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1.
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SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1.
SHIN2 increases survival in NOTCH1-driven mouse primary T-ALL in vivo.
Low dose methotrexate sensitizes Molt4 human T-ALL cells to SHIN2, and cells rendered methotrexate resistant in vitro show enhanced sensitivity to SHIN2.
SHIN2 and methotrexate synergize in mouse primary T-ALL and in a human patient-derived xenograft in vivo, increasing survival.
| M.Wt | 406.486 | |
| Formula | C23H26N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Juan C García-Cañaveras, et al. Leukemia. 2021 Feb;35(2):377-388.
2. Gregory S Ducker, et al. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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